Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

A better understanding of the mechanisms that generate and modulate uterine contractility is
needed if progress is to be made in the prevention or treatment of problems in labour …

Key points• Feed arteries and arterioles, respectively, control the magnitude and distribution
of blood flow to skeletal muscle but regional differences in the regulation of vasomotor tone …

There is a growing body of evidence indicating that transient receptor potential (TRP)
channels are implicated in calcium signaling and various cellular functions in the pulmonary …

Ca2+ release via type 2 ryanodine receptors (RyR2) regulates cardiac function. Molecular
cloning of human RyR2 identified 2 alternatively spliced variants, comprising 30-and 24-bp …

With the discovery of local Ca 2+ signals in the 1990s the concept of 'elementary Ca 2+
signals' and 'fundamental Ca 2+ signals' was developed. While 'elementary Ca 2+ signals' …

The cerebral blood supply is delivered by a surface network of pial arteries and arterioles
from which arise (parenchymal) arterioles that penetrate into the cortex and terminate in a …

Large conductance Ca 2+-activated K+(BK) channels play essential roles in both excitable
and non-excitable cells. For example, in chondrocytes, agonist-induced Ca 2+ release from …