[HTML][HTML] Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines
With increasing demand for donor organs for transplantation, machine perfusion (MP)
promises to be a beneficial alternative preservation method for donor livers, particularly …
promises to be a beneficial alternative preservation method for donor livers, particularly …
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is
currently limited by organ shortage. One technical challenge that has thus far limited the …
currently limited by organ shortage. One technical challenge that has thus far limited the …
The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury
The primary objective of organ preservation is to deliver a viable graft with minimal risk of
impaired postoperative graft function. In current clinical practice, preservation of transplanted …
impaired postoperative graft function. In current clinical practice, preservation of transplanted …
Partial freezing of rat livers extends preservation time by 5-fold
The limited preservation duration of organs has contributed to the shortage of organs for
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
Long-term ex situ normothermic perfusion of human split livers for more than 1 week
NS Lau, M Ly, C Dennis, A Jacques… - Nature …, 2023 - nature.com
Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …
Supercooling enables long-term transplantation survival following 4 days of liver preservation
The realization of long-term human organ preservation will have groundbreaking effects on
the current practice of transplantation. Herein we present a new technique based on …
the current practice of transplantation. Herein we present a new technique based on …
Warm vs. cold perfusion techniques to rescue rodent liver grafts
Background & Aims A variety of liver perfusion techniques have been proposed to protect
liver grafts prior to implantation. We compared hypothermic and normothermic oxygenated …
liver grafts prior to implantation. We compared hypothermic and normothermic oxygenated …
Hypothermic oxygenated perfusion (HOPE) protects from biliary injury in a rodent model of DCD liver transplantation
Background & Aims The use of livers from donors after cardiac arrest (DCD) is increasing in
many countries to overcome organ shortage. Due to additional warm ischemia before …
many countries to overcome organ shortage. Due to additional warm ischemia before …
[PDF][PDF] Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers
Q Liu, A Nassar, K Farias, L Buccini… - Liver …, 2014 - Wiley Online Library
The effects of normothermic machine perfusion (NMP) on the postreperfusion
hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) …
hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) …
Extracellular vesicles from human liver stem cells reduce injury in an ex vivo normothermic hypoxic rat liver perfusion model
F Rigo, N De Stefano, V Navarro-Tableros… - …, 2018 - journals.lww.com
Background The gold standard for organ preservation before transplantation is static cold
storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury …
storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury …