Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis
S Yogosawa, K Yoshida - Cancer science, 2018 - Wiley Online Library
Tumor suppressor p53 plays an important role in cancer prevention. Under normal
conditions, p53 is maintained at a low level. However, in response to various cellular …
conditions, p53 is maintained at a low level. However, in response to various cellular …
The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis
Despite the fundamental importance of proteasomal degradation in cells, little is known
about whether and how the 26S proteasome itself is regulated in coordination with various …
about whether and how the 26S proteasome itself is regulated in coordination with various …
FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2
R Jiménez-Izquierdo, R Morrugares… - Cell Death & …, 2023 - nature.com
FBXW7 is a member of the F-box protein family, which functions as the substrate recognition
component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its …
component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its …
Emerging roles of DYRK2 in cancer
Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition
M Soundararajan, AK Roos, P Savitsky… - Structure, 2013 - cell.com
Summary Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key
roles in brain development, regulation of splicing, and apoptosis, and are potential drug …
roles in brain development, regulation of splicing, and apoptosis, and are potential drug …
[HTML][HTML] Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA
demethylation has fundamentally changed the notion of how DNA methylation is regulated …
demethylation has fundamentally changed the notion of how DNA methylation is regulated …
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery
Y Gao, SP Davies, M Augustin, A Woodward… - Biochemical …, 2013 - portlandpress.com
Despite the development of a number of efficacious kinase inhibitors, the strategies for
rational design of these compounds have been limited by target promiscuity. In an effort to …
rational design of these compounds have been limited by target promiscuity. In an effort to …
An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
Over the past decade, Clk1 has been identified as a promising target for the treatment of
various diseases, in which deregulated alternative splicing plays a role. First small …
various diseases, in which deregulated alternative splicing plays a role. First small …
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival
M Lara-Chica, A Correa-Sáez… - Cell Death & …, 2022 - nature.com
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …