The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

PURPOSE: Much current research on lower urinary tract physiology focuses on afferent
mechanisms. The main goals are to define and control the signaling pathways by which …

Study Type–Aetiology (case control) Level of Evidence 3b OBJECTIVE To investigate the
progression of urodynamic changes, as well as histological and biochemical outcomes over …

The internal face of the detrusor smooth muscle wall of the urinary bladder is covered by a
mucosa, separating muscle from the hostile environment of urine. However, the mucosa is …

Aims This review summarizes the currently available literature on the localization and
proposed functions of a novel group of cells in the urinary bladder known as interstitial cells …

CONTEXT: The focus of clinical understanding and management of male storage lower
urinary tract symptoms (LUTS) has shifted from the prostate to the bladder. This is mirrored …

The lower urinary tract is a muscular system composed of the urinary bladder and the
outflow tract. During filling with urine the bladder is relaxed and the outflow tract offers a high …

The pathophysiology of lower urinary tract symptoms (LUTS), detrusor overactivity (DO), and
the overactive bladder (OAB) syndrome is multifactorial and remains poorly understood.• …

Aims To discuss (1) mechanisms involved in the generation and control of myocyte
contractions and consequent afferent nerve activity and (2) these mechanisms as targets for …

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical
contents of the lower urinary tract and the underlying tissues but also acts as a sensory …