Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

L Mashouri, H Yousefi, AR Aref, A Ahadi, F Molaei… - Molecular cancer, 2019 - Springer
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

ALIX-and ESCRT-III–dependent sorting of tetraspanins to exosomes

J Larios, V Mercier, A Roux, J Gruenberg - Journal of Cell Biology, 2020 - rupress.org
The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …

Establishing and regulating the composition of cilia for signal transduction

MV Nachury, DU Mick - Nature reviews Molecular cell biology, 2019 - nature.com
The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

[HTML][HTML] Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

JM Essola, M Zhang, H Yang, F Li, B **a… - Bioactive Materials, 2024 - Elsevier
Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

Inside (sight) of tiny communicator: exosome biogenesis, secretion, and uptake

AS Jadli, N Ballasy, P Edalat, VB Patel - Molecular and cellular …, 2020 - Springer
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …

The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …