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Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
Shedding light on extracellular vesicle biogenesis and bioengineering
F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …
Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
ALIX-and ESCRT-III–dependent sorting of tetraspanins to exosomes
The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …
receptors and other proteins to lysosomes for degradation, but they also modulate …
Establishing and regulating the composition of cilia for signal transduction
The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
[HTML][HTML] Exosome regulation of immune response mechanism: Pros and cons in immunotherapy
Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …
between different tissues, the exosomes are the extracellular vesicles arousing the highest …
Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
Inside (sight) of tiny communicator: exosome biogenesis, secretion, and uptake
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …
The role and applications of extracellular vesicles in osteoporosis
F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …