Potential targets for next generation antimicrobial glycoconjugate vaccines
F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for develo** vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Cholera: immunity and prospects in vaccine development
JB Harris - The Journal of infectious diseases, 2018 - academic.oup.com
Vibrio cholerae is a prototypical noninvasive mucosal pathogen, yet infection generates long-
lasting protection against subsequent disease. Vibriocidal antibody responses are an …
lasting protection against subsequent disease. Vibriocidal antibody responses are an …
Emerging concepts in cholera vaccine design
Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae and
constitutes a significant public health threat in many areas of the world. V. cholerae infection …
constitutes a significant public health threat in many areas of the world. V. cholerae infection …
Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development
Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease
affecting millions worldwide each year. Cholera is a major public health problem, primarily in …
affecting millions worldwide each year. Cholera is a major public health problem, primarily in …
Single-cell analysis of the plasmablast response to Vibrio cholerae demonstrates expansion of cross-reactive memory B cells
RC Kauffman, TR Bhuiyan, R Nakajima… - MBio, 2016 - Am Soc Microbiol
We characterized the acute B cell response in adults with cholera by analyzing the
repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) …
repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) …
Virus-like Particle Display of Vibrio cholerae O-Specific Polysaccharide as a Potential Vaccine against Cholera
Z Rashidijahanabad, M Kelly… - ACS infectious …, 2022 - ACS Publications
Vibrio cholerae, a noninvasive mucosal pathogen, is endemic in more than 50 countries.
Oral cholera vaccines, based on killed whole-cell strains of Vibrio cholerae, can provide …
Oral cholera vaccines, based on killed whole-cell strains of Vibrio cholerae, can provide …
Recent advances in lipopolysaccharide-based glycoconjugate vaccines
Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …
[HTML][HTML] Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid …
M Kelly, A Mandlik, RC Charles, S Verma… - Vaccine, 2023 - Elsevier
There is a need for vaccines effective against shigella infection in young children in resource-
limited areas. Protective immunity against shigella infection targets the O-specific …
limited areas. Protective immunity against shigella infection targets the O-specific …
Preclinical development of a fusion peptide conjugate as an HIV vaccine immunogen
The vaccine elicitation of broadly neutralizing antibodies against HIV-1 is a long-sought
goal. We previously reported the amino-terminal eight residues of the HIV-1-fusion peptide …
goal. We previously reported the amino-terminal eight residues of the HIV-1-fusion peptide …