Life on earth is almost entirely solar-powered. We can get some idea of the enormous
quantity of energy received from the sun by noting that during daylight hours, the sun …

The number of known three-dimensional structures of vitamin B6-dependent enzymes has
doubled in the past two years. A fourth type of fold for B6-dependent enzymes, involving a …

Metal complexation is a key mediator or modifier of enzyme structure and function. In
addition to divalent and polyvalent metals, group IA metals Na+ and K+ play important and …

This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …

Enzymes catalyze a plethora of chemical reactions in nature. These biocatalysts offer a
variety of benefits that no other synthetic catalyst can offer: high turnover, regio-and …

The pyridoxal-5-phosphate-dependent enzymes (B6 enzymes) that act on amino acid
substrates are of multiple evolutionary origin. The numerous common mechanistic features …

Arginine residues are generally considered poor candidates for the role of general bases
because they are predominantly protonated at physiological pH. Nonetheless, Arg residues …

Regulation of enzymes through metal ion complexation is widespread in biology and
underscores a physiological need for stability and high catalytic activity that likely predated …

The three-dimensional structure of diaminopelargonic acid synthase, a vitamin B6-
dependent enzyme in the pathway of the biosynthesis of biotin, has been determined to 1.8 …

Abstract Pyridoxal-5′-phosphate (PLP) is a versatile cofactor that enzymes use to catalyze
a wide variety of reactions of amino acids, including transamination, decarboxylation …