Advances and challenges in time-resolved macromolecular crystallography
BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
Mitochondrial structure and bioenergetics in normal and disease conditions
M Protasoni, M Zeviani - International journal of molecular sciences, 2021 - mdpi.com
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …
involved in various aspects of cellular life, with a primary role in energy production. The …
Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to more than 270 million
infections and 5.3 million of deaths worldwide. Several major variants of SARS-CoV-2 have …
infections and 5.3 million of deaths worldwide. Several major variants of SARS-CoV-2 have …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
[HTML][HTML] Recent results in time resolved serial femtosecond crystallography at XFELs
AM Orville - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Time-resolved serial femtosecond crystallography (tr-SFX) probes structure and
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase
C Safari, S Ghosh, R Andersson, J Johannesson… - Science …, 2023 - science.org
Cytochrome c oxidase (C c O) is part of the respiratory chain and contributes to the
electrochemical membrane gradient in mitochondria as well as in many bacteria, as it uses …
electrochemical membrane gradient in mitochondria as well as in many bacteria, as it uses …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
Role of carbon monoxide in host–gut microbiome communication
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase
I Ishigami, A Lewis-Ballester… - Proceedings of the …, 2019 - National Acad Sciences
Cytochrome c oxidase (C c O) reduces dioxygen to water and harnesses the chemical
energy to drive proton translocation across the inner mitochondrial membrane by an …
energy to drive proton translocation across the inner mitochondrial membrane by an …
Carbon monoxide–beyond toxicity?
D Stucki, W Stahl - Toxicology letters, 2020 - Elsevier
Carbon monoxide (CO) intoxication is one of the most frequent causes of accidental
poisoning, mechanistically related to the inhibition of oxygen transport following blockage of …
poisoning, mechanistically related to the inhibition of oxygen transport following blockage of …