DNA damage—how and why we age?
Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …
Fanconi anaemia and cancer: an intricate relationship
G Nalepa, DW Clapp - Nature Reviews Cancer, 2018 - nature.com
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
Human RecQ helicases in DNA repair, recombination, and replication
DL Croteau, V Popuri, PL Opresko… - Annual review of …, 2014 - annualreviews.org
RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
Nuclear genomic instability and aging
The nuclear genome decays as organisms age. Numerous studies demonstrate that the
burden of several classes of DNA lesions is greater in older mammals than in young …
burden of several classes of DNA lesions is greater in older mammals than in young …
Vegetables and their bioactive compounds as anti-aging drugs
Aging is a continuous process over time that is mainly related to natural alterations in
mechanical–biological processes. This phenomenon is due to several factors, including the …
mechanical–biological processes. This phenomenon is due to several factors, including the …
Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence
J Yao, D Ding, X Li, T Shen, H Fu, H Zhong, G Wei… - Aging cell, 2020 - Wiley Online Library
Intron retention (IR) is the least well‐understood alternative splicing type in animals, and its
prevalence and function in physiological and pathological processes have long been …
prevalence and function in physiological and pathological processes have long been …
Mutations in ANAPC1, encoding a scaffold subunit of the anaphase-promoting complex, cause Rothmund-Thomson syndrome type 1
NF Ajeawung, TTM Nguyen, L Lu, TJ Kucharski… - The American Journal of …, 2019 - cell.com
Rothmund-Thomson syndrome (RTS) is an autosomal-recessive disorder characterized by
poikiloderma, sparse hair, short stature, and skeletal anomalies. Type 2 RTS, which is …
poikiloderma, sparse hair, short stature, and skeletal anomalies. Type 2 RTS, which is …
[HTML][HTML] Skin abnormalities in disorders with DNA repair defects, premature aging, and mitochondrial dysfunction
Defects in DNA repair pathways and alterations of mitochondrial energy metabolism have
been reported in multiple skin disorders. More than 10% of patients with primary …
been reported in multiple skin disorders. More than 10% of patients with primary …