Decipher the glioblastoma microenvironment: the first milestone for new groundbreaking therapeutic strategies

GN Fanelli, D Grassini, V Ortenzi, F Pasqualetti… - Genes, 2021 - mdpi.com
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite
the combination of novel therapeutical approaches, it remains a deadly malignancy with an …

An overview of mesenchymal stem cells and their potential therapeutic benefits in cancer therapy

SK Lim, BY Khoo - Oncology Letters, 2021 - spandidos-publications.com
There has been increased interest in using stem cells for regenerative medicine and cancer
therapy in the past decade. Mesenchymal stem cells (MSCs) are among the most studied …

Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

KA Snyder, MR Hughes, B Hedberg, J Brandon… - Breast cancer …, 2015 - Springer
Introduction Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in
the regulation of cell adhesion, migration and polarity. Upregulated expression of …

Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

A Román-Fernández, MA Mansour, FG Kugeratski… - Science …, 2023 - science.org
The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal
tissue development by promoting apical membranes to form between cells, triggering lumen …

Bivalent chromatin domains in glioblastoma reveal a subtype-specific signature of glioma stem cells

AW Hall, AM Battenhouse, H Shivram, AR Morris… - Cancer research, 2018 - AACR
Glioblastoma multiforme (GBM) can be clustered by gene expression into four main
subtypes associated with prognosis and survival, but enhancers and other gene-regulatory …

A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors

D Bohaciakova, M Hruska-Plochan… - Stem cell research & …, 2019 - Springer
Background A well-characterized method has not yet been established to reproducibly,
efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem …

Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage

K Ogawa, A Kurose, A Kamataki, K Asano… - Brain tumor …, 2020 - Springer
Giant cell glioblastoma (GC-GBM) consists of large cells with pleomorphic nuclei. As a
contrast to GC-GBM, we defined monotonous small GBM (MS-GBM) as GBM that consists of …

Prognostic role of podocalyxin-like protein expression in various cancers: A systematic review and meta-analysis

J Wang, Y Zhao, R Qi, X Zhu, C Huang, S Cheng… - …, 2016 - pmc.ncbi.nlm.nih.gov
Several studies were conducted to explore the prognostic significance of podocalyxin-like
protein (PODXL) expression in various cancers, with contradictory. This study aims to …

Naringin suppresses the development of glioblastoma by inhibiting FAK activity

J Li, Y Dong, G Hao, B Wang, J Wang… - Journal of drug …, 2017 - Taylor & Francis
As the most common and lethal primary malignant brain cancer, glioblastoma is hard to
timely diagnose and sensitive therapeutic monitoring. It is essential to develop new and …

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics …

J Melrose - Journal of Neuroscience Research, 2024 - Wiley Online Library
Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse
functional roles, this study examined how these control cellular behavior and tissue function …