Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection
In response to emerging infectious diseases, such as the recent pandemic of coronavirus
disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 …
disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 …
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma
J Geng, L Chen, Y Yuan, K Wang, Y Wang… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …
Measuring the human immune response to surgery: multiomics for the prediction of postoperative outcomes
The comprehensive and single-cell characterization of the human immune response to
surgery has significantly advanced our ability to predict the risk of postoperative …
surgery has significantly advanced our ability to predict the risk of postoperative …
Discovery of sparse, reliable omic biomarkers with Stabl
Adoption of high-content omic technologies in clinical studies, coupled with computational
methods, has yielded an abundance of candidate biomarkers. However, translating such …
methods, has yielded an abundance of candidate biomarkers. However, translating such …
Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
KE Happonen, PG Burrola, G Lemke - Communications Biology, 2023 - nature.com
The receptor tyrosine kinase Mer (gene name Mertk) acts in vascular endothelial cells (ECs)
to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is …
to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is …
Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function
Aims Long-COVID occurs after SARS-CoV-2 infection and results in diverse, prolonged
symptoms. The present study aimed to unveil potential mechanisms, and to inform prognosis …
symptoms. The present study aimed to unveil potential mechanisms, and to inform prognosis …
COVID‐19 plasma proteome reveals novel temporal and cell‐specific signatures for disease severity and high‐precision disease management
Abstract Coronavirus disease 2019 (COVID‐19) is a systemic inflammatory condition with
high mortality that may benefit from personalized medicine and high‐precision approaches …
high mortality that may benefit from personalized medicine and high‐precision approaches …
Identification of human genetic variants modulating the course of COVID-19 infection with importance in other viral infections
Introduction: COVID-19 has been a major focus of scientific research since early 2020. Due
to its societal, economic, and clinical impact worldwide, research efforts aimed, among other …
to its societal, economic, and clinical impact worldwide, research efforts aimed, among other …
Plasma proteomics identify potential severity biomarkers from COVID‐19 associated network
Abstract Purpose Coronavirus disease 2019 (COVID‐19) continues to threaten public health
globally. Severe acute respiratory coronavirus type 2 (SARS‐CoV‐2) infection‐dependent …
globally. Severe acute respiratory coronavirus type 2 (SARS‐CoV‐2) infection‐dependent …