Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Exploring giant unilamellar vesicle production for artificial cells—Current challenges and future directions
Creating an artificial cell from the bottom up is a long‐standing challenge and, while
significant progress has been made, the full realization of this goal remains elusive …
significant progress has been made, the full realization of this goal remains elusive …
Bottom-up assembly of synthetic cells with a DNA cytoskeleton
Cytoskeletal elements, like actin and myosin, have been reconstituted inside lipid vesicles
toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo …
toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo …
Modulating the lifetime of DNA motifs using visible light and small molecules
Here we regulate the formation of dissipative assemblies built from DNA using a
merocyanine photoacid that responds to visible light. The operation of our system and the …
merocyanine photoacid that responds to visible light. The operation of our system and the …
Building a community to engineer synthetic cells and organelles from the bottom-up
Employing concepts from physics, chemistry and bioengineering,'learning-by-
building'approaches are becoming increasingly popular in the life sciences, especially with …
building'approaches are becoming increasingly popular in the life sciences, especially with …
Modularized synthetic biology enabled intelligent biosensors
Biosensors that sense the concentration of a specified target and produce a specific signal
output have become important technology for biological analysis. Recently, intelligent …
output have become important technology for biological analysis. Recently, intelligent …
Two‐Photon 3D Laser Printing Inside Synthetic Cells
Toward the ambitious goal of manufacturing synthetic cells from the bottom up, various
cellular components have already been reconstituted inside lipid vesicles. However, the …
cellular components have already been reconstituted inside lipid vesicles. However, the …
Modulating lipid membrane morphology by dynamic DNA origami networks
Membrane morphology and its dynamic adaptation regulate many cellular functions, which
are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled …
are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled …
Engineering DNA-based cytoskeletons for synthetic cells
The development and bottom-up assembly of synthetic cells with a functional cytoskeleton
sets a major milestone to understand cell mechanics and to develop man-made machines …
sets a major milestone to understand cell mechanics and to develop man-made machines …
Extracellular cues govern shape and cytoskeletal organization in giant unilamellar lipid vesicles
A Fink, CR Doll, A Yagüe Relimpio… - ACS Synthetic …, 2023 - ACS Publications
Spontaneous and induced front-rear polarization and a subsequent asymmetric actin
cytoskeleton is a crucial event leading to cell migration, a key process involved in a variety of …
cytoskeleton is a crucial event leading to cell migration, a key process involved in a variety of …