Drug repurposing: progress, challenges and recommendations
Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …
development, repurposing of'old'drugs to treat both common and rare diseases is …
Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues
M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
immunological, and genetic factors. Alterations in the gut microbiota have been associated …
Functional map** and annotation of genetic associations with FUMA
K Watanabe, E Taskesen, A Van Bochoven… - Nature …, 2017 - nature.com
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal
variants. Results from GWAS typically do not directly translate into causal variants because …
variants. Results from GWAS typically do not directly translate into causal variants because …
Genome-wide enhancer maps link risk variants to disease genes
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …
are associated with human diseases and complex traits, each of which could reveal insights …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …
association with human disease, but epigenomic studies lack a similar reference. To …
Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations …
1.2. Definitions Ulcerative colitis [UC] is a chronic inflammatory condition that causes
continuous mucosal inflammation of the colon, usually without granulomas on biopsy. It …
continuous mucosal inflammation of the colon, usually without granulomas on biopsy. It …
Gut microbiota and IBD: causation or correlation?
J Ni, GD Wu, L Albenberg, VT Tomov - Nature reviews Gastroenterology …, 2017 - nature.com
A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
ACG clinical guideline: management of Crohn's disease in adults
Crohn's disease is an idiopathic inflammatory disorder of unknown etiology with genetic,
immunologic, and environmental influences. The incidence of Crohn's disease has steadily …
immunologic, and environmental influences. The incidence of Crohn's disease has steadily …
Interactions between the microbiota and the immune system
LV Hooper, DR Littman, AJ Macpherson - science, 2012 - science.org
The large numbers of microorganisms that inhabit mammalian body surfaces have a highly
coevolved relationship with the immune system. Although many of these microbes carry out …
coevolved relationship with the immune system. Although many of these microbes carry out …
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
D Welter, J MacArthur, J Morales, T Burdett… - Nucleic acids …, 2014 - academic.oup.com
Abstract The National Human Genome Research Institute (NHGRI) Catalog of Published
Genome-Wide Association Studies (GWAS) Catalog provides a publicly available manually …
Genome-Wide Association Studies (GWAS) Catalog provides a publicly available manually …