Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the
market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 …

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

Thrombosis is the most common underlying pathology responsible for morbidity and
mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation …

Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia in the
elderly. AD is accompanied by the accumulation of amyloid peptides in the brain …

The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is
predicted to increase due to the shift in age of the general population and increase in CVD …

Abstract Platelet-type lipoxygenase (pl12-LOX), encoded by ALOX12, catalyzes the
production of the lipid mediator 12S-hydroperoxyeicosa-5, 8, 10, 14-tetraenoic acid (12S …

With the diet, we ingest nutrients capable of modulating platelet function, which plays a
crucial role in develo** cardiovascular events, one of the leading causes of mortality …

Platelets are key contributors to the formation of occlusive thrombi; the major underlying
cause of ischemic heart disease and stroke. Antiplatelet therapy has reduced the morbidity …

Cardiovascular diseases are the leading cause of death in the world. Platelets have a major
role in cardiovascular events as they bind to the damaged endothelium activating and …