Pathophysiology of spinal cord injury

LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
Spinal cord injury (SCI) triggers a complex cascade of molecular and chemical events that
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …

In vivo functions of p75NTR: Challenges and opportunities for an emerging therapeutic target

SC Malik, EG Sozmen, B Baeza-Raja… - Trends in …, 2021 - cell.com
The p75 neurotrophin receptor (p75 NTR) functions at the molecular nexus of cell death,
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …

Molecular mechanisms of neurogenic lower urinary tract dysfunction after spinal cord injury

N Shimizu, T Saito, N Wada, M Hashimoto… - International journal of …, 2023 - mdpi.com
This article provides a synopsis of current progress made in fundamental studies of lower
urinary tract dysfunction (LUTD) after spinal cord injury (SCI) above the sacral level. Animal …

Nerve growth factor pathobiology during the progression of Alzheimer's disease

EJ Mufson, SE Counts, SD Ginsberg… - Frontiers in …, 2019 - frontiersin.org
The current review summarizes the pathobiology of nerve growth factor (NGF) and its
cognate receptors during the progression of Alzheimer's disease (AD). Both transcript and …

[HTML][HTML] Current knowledge and novel frontiers in lower urinary tract dysfunction after spinal cord injury: Basic research perspectives

N Wada, S Karnup, K Kadekawa, N Shimizu… - Urological …, 2022 - journals.lww.com
This review article aims to summarize the recent advancement in basic research on lower
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …

Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury

Y Liu, C Zhao, R Zhang, Y Pang, L Li… - Stem Cell Research & …, 2024 - Springer
Spinal cord injury (SCI) results in significant neural damage and inhibition of axonal
regeneration due to an imbalanced microenvironment. Extensive evidence supports the …

Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation

SS Chambel, CD Cruz - Neural Regeneration Research, 2023 - journals.lww.com
Axonal growth inhibitors are released during traumatic injuries to the adult mammalian
central nervous system, including after spinal cord injury. These molecules accumulate at …

P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases

LL **ong, L Chen, IB Deng, XF Zhou… - European Journal of …, 2022 - Wiley Online Library
The interaction of neurotrophins with their receptors is involved in the pathogenesis and
progression of various neurological diseases, including Alzheimer's disease, Parkinson's …

The effect of iPS-derived neural progenitors seeded on laminin-coated pHEMA-MOETACl hydrogel with dual porosity in a rat model of chronic spinal cord injury

J Ruzicka, N Romanyuk, K Jirakova… - Cell …, 2019 - journals.sagepub.com
Spinal cord injury (SCI), is a devastating condition leading to the loss of locomotor and
sensory function below the injured segment. Despite some progress in acute SCI treatment …

[HTML][HTML] Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: Molecular mechanism

Y Wang, ZL **ong, XL Ma, C Zhou… - Neural Regeneration …, 2022 - journals.lww.com
Previous studies showed that acetyl-11-keto-beta-boswellic acid (AKBA), the active
ingredient in the natural Chinese medicine Boswellia, can stimulate sciatic nerve injury …