Mutations in genes that constitute the phosphatidylinositol 3-kinase (PI3K) pathway occur
in> 70% of breast cancers. Clinical and experimental evidence suggest that PI3K pathway …

When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …

Ductal carcinoma in situ (DCIS) is an often-diagnosed breast disease and a known, non-
obligate, precursor to invasive breast carcinoma. In this review, we explore the clinical and …

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway mediates the effects of a variety of
extracellular signals in a number of cellular processes including cell growth, proliferation …

Purpose: PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway.
Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In …

PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one
of the most frequently mutated genes in human breast cancer. Here, we describe a mouse …

The PIK3 signaling pathway has been identified as one of the most important and most
frequently mutated pathways in breast cancer. Somatic mutations in the catalytic subunit of …

The increasing interest of the oncology community in tumour classification and prediction of
outcome to targeted therapies has put emphasis on an improved identification of tumour …

Invasive, genetically abnormal carcinoma progenitor cells have been propagated from
human and mouse breast ductal carcinoma in situ (DCIS) lesions, providing new insights …

Abstract The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha
(PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs) …