Molecular Diversity of K+ Channels

WA Coetzee, Y Amarillo, J Chiu, A Chow… - Annals of the New …, 1999 - Wiley Online Library
K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

Cardiac ionic currents and acute ischemia: from channels to arrhythmias

E Carmeliet - Physiological reviews, 1999 - journals.physiology.org
The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Pharmacology of cardiac potassium channels

J Tamargo, R Caballero, R Gómez… - Cardiovascular …, 2004 - academic.oup.com
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

Differential Expression of Kv4 K+ Channel Subunits Mediating Subthreshold Transient K+ (A-Type) Currents in Rat Brain

P Serôdio, B Rudy - Journal of neurophysiology, 1998 - journals.physiology.org
Serôdio, Paulo and Bernardo Rudy. Differential expression of Kv4 K+ channel subunits
mediating subthreshold transient K+ (A-type) currents in rat brain. J. Neurophysiol. 79: 1081 …

Structure and function of Kv4-family transient potassium channels

SG Birnbaum, AW Varga, LL Yuan… - Physiological …, 2004 - journals.physiology.org
Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC

DA Hoffman, D Johnston - Journal of Neuroscience, 1998 - Soc Neuroscience
We have reported recently a high density of transient A-type K+ channels located in the
distal dendrites of CA1 hippocampal pyramidal neurons and shown that these channels …

Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways

B Hegyi, JM Borst, LRJ Bailey, EY Shen… - Basic research in …, 2020 - Springer
Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel
remodeling and increased arrhythmia risk. However, the exact signaling mechanism by …

Structure and function of cardiac potassium channels

DJ Snyders - Cardiovascular research, 1999 - academic.oup.com
Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

Molecular physiology and modulation of somatodendritic A-type potassium channels

HH Jerng, PJ Pfaffinger, M Covarrubias - Molecular and Cellular …, 2004 - Elsevier
The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Molecular determinants of cardiac transient outward potassium current (Ito) expression and regulation

N Niwa, JM Nerbonne - Journal of molecular and cellular cardiology, 2010 - Elsevier
Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …