Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most
common form of glaucoma. Because the disease is treatable, and because the visual …

Müller glial cells span the entire thickness of the tissue, and ensheath all retinal neurons, in
vertebrate retinae of all species. This morphological relationship is reflected by a multitude …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Glaucoma is recognized to have its major detrimental effect upon the eye by killing retinal
ganglion cells. The process of cell death appears to be initiated at the optic nerve head …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand
neural injury in the visual system. This paradigm may stimulate the discovery of innovative …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

purpose. To investigate the relationship between ganglion cell losses and visual field
defects caused by glaucoma. methods. Behavioral perimetry and histology data were …

purpose. To determine the expression and localization of tumor necrosis factor (TNF)-α and
TNF-α receptor-1 in the retina of normal and glaucomatous eyes. methods. Using …