The immunology and immunopathology of COVID-19
Considerable research effort has been made worldwide to decipher the immune response
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …
Pathological sequelae of long-haul COVID
S Mehandru, M Merad - Nature immunology, 2022 - nature.com
The world continues to contend with successive waves of coronavirus disease 2019 (COVID-
19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and …
19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and …
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …
[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …
production, viral RNA and a sustained interferon (IFN) response, all of which are …
New-onset IgG autoantibodies in hospitalized patients with COVID-19
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune
features and autoantibody production. Here we develop three protein arrays to measure IgG …
features and autoantibody production. Here we develop three protein arrays to measure IgG …
Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …
to acute respiratory distress syndrome and death. Three highly pathogenic human …
Global absence and targeting of protective immune states in severe COVID-19
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …
pleiotropic and systemic effects in some individuals,–, many others experience milder …