[HTML][HTML] MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions

VP Wagner, CD Bingle, L Bingle - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
Adenoid cystic carcinoma (ACC) is the most common type of salivary gland cancer that can
also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent …

Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor

C Emerick, FV Mariano, PA Vargas, JE Nör… - Critical reviews in …, 2022 - Elsevier
Adenoid cystic carcinoma (ACC) is a biphasic malignant lesion that can develop at various
anatomical sites. Salivary and lacrimal ACC lesions have a high risk of local invasion …

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

P Bandopadhayay, LA Ramkissoon, P Jain… - Nature …, 2016 - nature.com
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent
genetic drivers. We performed genomic analysis of new and published data from 249 …

Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor–Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma

KJ Brayer, CA Frerich, H Kang, SA Ness - Cancer discovery, 2016 - aacrjournals.org
Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …

Novel MYBL1 Gene Rearrangements with Recurrent MYBL1–NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations

Y Mitani, B Liu, PH Rao, VJ Borra, M Zafereo… - Clinical cancer …, 2016 - aacrjournals.org
Purpose: Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy,
characterized by t (6; 9) translocations and MYB–NFIB gene fusions in approximately 50% of …

The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains

AA Alekseyenko, EM Walsh, X Wang… - Genes & …, 2015 - genesdev.cshlp.org
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

[HTML][HTML] A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma

AL Ho, L Dunn, EJ Sherman, MG Fury, SS Baxi… - Annals of …, 2016 - Elsevier
Background Recurrent/metastatic adenoid cystic carcinoma (ACC) is an incurable disease
with no standard treatments. The majority of ACCs express the oncogenic transcription factor …

Targeting the oncogenic transcriptional regulator MYB in adenoid cystic carcinoma by inhibition of IGF1R/AKT signaling

MK Andersson, MK Afshari, Y Andrén… - JNCI: Journal of the …, 2017 - academic.oup.com
Background Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative
treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the …

Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review

Z Chen, J Jiang, Y Fan, H Lu - Diagnostic Pathology, 2023 - Springer
Background Pulmonary adenoid cystic carcinoma (PACC) is an exceptionally rare salivary
gland-type malignant neoplasm. Because of its clinical manifestations, imaging features are …

Whole-genome sequencing of salivary gland adenoid cystic carcinoma

EM Rettig, CC Talbot Jr, M Sausen… - Cancer Prevention …, 2016 - aacrjournals.org
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat,
and cure. To better understand the genetic alterations underlying the pathogenesis of these …