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[HTML][HTML] MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions
Adenoid cystic carcinoma (ACC) is the most common type of salivary gland cancer that can
also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent …
also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent …
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor
Adenoid cystic carcinoma (ACC) is a biphasic malignant lesion that can develop at various
anatomical sites. Salivary and lacrimal ACC lesions have a high risk of local invasion …
anatomical sites. Salivary and lacrimal ACC lesions have a high risk of local invasion …
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
P Bandopadhayay, LA Ramkissoon, P Jain… - Nature …, 2016 - nature.com
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent
genetic drivers. We performed genomic analysis of new and published data from 249 …
genetic drivers. We performed genomic analysis of new and published data from 249 …
Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor–Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma
Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …
Novel MYBL1 Gene Rearrangements with Recurrent MYBL1–NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations
Purpose: Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy,
characterized by t (6; 9) translocations and MYB–NFIB gene fusions in approximately 50% of …
characterized by t (6; 9) translocations and MYB–NFIB gene fusions in approximately 50% of …
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
AA Alekseyenko, EM Walsh, X Wang… - Genes & …, 2015 - genesdev.cshlp.org
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …
aggressive human solid malignancies known. NMC is driven by the creation of a …
[HTML][HTML] A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma
Background Recurrent/metastatic adenoid cystic carcinoma (ACC) is an incurable disease
with no standard treatments. The majority of ACCs express the oncogenic transcription factor …
with no standard treatments. The majority of ACCs express the oncogenic transcription factor …
Targeting the oncogenic transcriptional regulator MYB in adenoid cystic carcinoma by inhibition of IGF1R/AKT signaling
MK Andersson, MK Afshari, Y Andrén… - JNCI: Journal of the …, 2017 - academic.oup.com
Background Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative
treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the …
treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the …
Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review
Z Chen, J Jiang, Y Fan, H Lu - Diagnostic Pathology, 2023 - Springer
Background Pulmonary adenoid cystic carcinoma (PACC) is an exceptionally rare salivary
gland-type malignant neoplasm. Because of its clinical manifestations, imaging features are …
gland-type malignant neoplasm. Because of its clinical manifestations, imaging features are …
Whole-genome sequencing of salivary gland adenoid cystic carcinoma
EM Rettig, CC Talbot Jr, M Sausen… - Cancer Prevention …, 2016 - aacrjournals.org
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat,
and cure. To better understand the genetic alterations underlying the pathogenesis of these …
and cure. To better understand the genetic alterations underlying the pathogenesis of these …