Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry,
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …

Solid dosage forms such as tablets are extensively used in drug administration for their
simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is …

Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim
was to gain information about their microstructure, and thus, derive deeper interpretation of …

In the present study the application of near-infrared chemical imaging (NIR-CI) supported by
chemometric modeling as non-destructive tool for monitoring and assessing the roller …

Dry granulation is an agglomeration process used to produce size-enlarged particles
(granules), improving the handling properties of powders such as flowability. In this process …

One of primary goals of the Quality by Design initiative in the pharmaceutical industry is to
reduce variation in the product quality through increased understanding and control of the …

Enabling the paradigm of quality by design requires the ability to quantitatively correlate
material properties and process variables to measureable product performance attributes. In …

Roll compaction/dry granulation often results in loss of tabletability. The two main
hypotheses for this are granule hardening and granule size enlargement. The aim of this …

The aim of this study was to investigate the role of porosity on the compression behavior and
tablet tensile strength for granules produced by a dry granulation procedure. Microcrystalline …

Johanson's roll compaction model [JR Johanson, A rolling theory for granular solids, ASME
Journal of Applied Mechanics E32 (1965) 842–848] is modified to improve its predictions of …