Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …

The coronavirus nonstructural protein (nsp) 13 encodes an RNA helicase (nsp13-HEL) with
multiple enzymatic functions, including unwinding and nucleoside phosphatase (NTPase) …

The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global
public health emergency. SARS-coronavirus-2 (SARS-CoV-2), the causative pathogen of …

Highlights•Enteroviruses cause many human diseases, yet no antiviral drugs are
available.•Capsids and viral enzymes are promising targets for direct-acting antiviral …

Enteroviruses are a group of RNA viruses belonging to the family Picornaviridae. They
include human enterovirus groups A, B, C, and D as well as non-human enteroviruses …

Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise
untreatable types of cancer. Despite encouraging developments in recent years, the limited …

Enteroviruses (family Picornaviridae) comprise a large group of human pathogens against
which no licensed antiviral therapy exists. Drug-repurposing screens uncovered the FDA …

Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute
gastroenteritis worldwide, particularly genogroup II genotype 4 (GII. 4) variants. The viral …

Hand-foot-mouth disease (HFMD) is a common viral disease in young children, mainly
caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Specific antiviral …

Enteroviruses (EVs) represent many important pathogens of humans. Unfortunately, no
antiviral compounds currently exist to treat infections with these viruses. We screened the …