Abstract One Von Hippel-Lindau (VHL) tumor suppressor gene is lost in most renal cell
carcinomas while the nondeleted allele exhibits hypermethylation-induced inactivation or …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be
expressed as mathematical models. To explore this further, quantitative analysis of the most …

Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate
metastatic tumor growth and decrease overall survival in mice receiving short-term therapy …

Tumor growth curves are classically modeled by means of ordinary differential equations. In
analyzing the Gompertz model several studies have reported a striking correlation between …

Purpose To assess the safety and efficacy of neoadjuvant bevacizumab with standard
chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response …

Disruption of the precise balance of positive and negative molecular regulators of blood and
lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors …

Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis
and that inhibiting this process might be a new strategy for cancer therapy. This hypothesis …

Purpose The receptors for hepatocyte and vascular endothelial cell growth factors (MET and
VEGFR2, respectively) are critical oncogenic mediators in gastric adenocarcinoma. The …

Vascular endothelial growth factor C (VEGF-C) has been identified as a multifaceted factor
participating in the regulation of tumor angiogenesis and lymphangiogenesis. VEGF-C is not …