We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …

Triterpenoids are structurally diverse organic compounds, characterized by a basic
backbone modified in multiple ways, allowing the formation of more than 20 000 naturally …

Although glycogen synthase kinase‐3 beta (GSK‐3β) was originally named for its ability to
phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional …

Over the last two decades, extensive research on plant-based medicinal compounds has
revealed exciting and important pharmacological properties and activities of triterpenoids …

Dysregulated cell cycling is a universal hallmark of cancer and is often mediated by
abnormal activation of cyclin-dependent kinases (CDKs) and their cyclin partners …

The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …

Osteoclast differentiation is a complex and finely regulated physiological process that
involves a variety of signaling pathways and factors. Recent studies suggested that the Ser9 …

Recent evidences suggest that the activity of glycogen synthase kinase-3 (GSK3)
contributes to the tumorigenic potential of pancreatic cancer cells through modulation of cell …

Furthermore, GSK 3β inhibitor SB216763 blocked the cleavages of caspase-3 and PARP
induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of β …

The existence of active principles in numerous foods and beverages has been recognized
by traditional medicines worldwide after centuries of empirical trial. Epidemiological studies …