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How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes
DL Goldenberg - Seminars in Arthritis and Rheumatism, 2024 - Elsevier
Long COVID should be limited to patients with multiple, persistent symptoms not related to
well-defined organ damage. Once redefined, a focused review of long COVID demonstrates …
well-defined organ damage. Once redefined, a focused review of long COVID demonstrates …
[HTML][HTML] Targeting members of the chemokine family as a novel approach to treating neuropathic pain
K Pawlik, J Mika - Molecules, 2023 - mdpi.com
Neuropathic pain is a debilitating condition that affects millions of people worldwide.
Numerous studies indicate that this type of pain is a chronic condition with a complex …
Numerous studies indicate that this type of pain is a chronic condition with a complex …
Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities
Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
Sigma-1 receptor inhibition reduces mechanical allodynia and modulate neuroinflammation in chronic neuropathic pain
Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an
injury or disease of the somatosensory nervous system, which induces abnormal painful …
injury or disease of the somatosensory nervous system, which induces abnormal painful …
The dual role of microglia in neuropathic pain after spinal cord injury: detrimental and protective effects
Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by
neuropathic pain, resulting in significant physical and psychological harm to a vast number …
neuropathic pain, resulting in significant physical and psychological harm to a vast number …
Assessing risk factors and comorbidities in the treatment of chronic pain: a narrative review
SV Hebert, MA Green, SA Mashaw… - Current Pain and …, 2024 - Springer
Abstract Purpose of Review Chronic pain affects a significant portion of the population
globally, making it a leading cause of disability. Understanding the multifaceted nature of …
globally, making it a leading cause of disability. Understanding the multifaceted nature of …
[PDF][PDF] Central sensitivity in fibromyalgia: testing a model to explain the role of psychological factors on functioning and quality of life
Objective Central sensitivity (CS) is defined as an increased responsiveness of nociceptive
neurons in the central nervous system to normal or subthreshold inputs. CS has recently …
neurons in the central nervous system to normal or subthreshold inputs. CS has recently …
Redox regulation of immunometabolism in microglia underpinning diabetic retinopathy
L Cai, M **a, F Zhang - Antioxidants, 2024 - mdpi.com
Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness among
the working-age population. Microglia, resident immune cells in the retina, are recognized …
the working-age population. Microglia, resident immune cells in the retina, are recognized …
[HTML][HTML] Exosomes derived from M2-type microglia ameliorate oxygen-glucose deprivation/reoxygenation-induced HT22 cell injury by regulating miR-124-3p/NCOA4 …
K **e, Y Mo, E Yue, N Shi, K Liu - Heliyon, 2023 - cell.com
Background Although it has been reported that miRNA carried by M2 microglial exosomes
protects neurons from ischemia–reperfusion brain injury, the mechanism of action remains …
protects neurons from ischemia–reperfusion brain injury, the mechanism of action remains …
Applying lessons from rheumatology to better understand long COVID
DL Goldenberg - Arthritis Care & Research, 2024 - Wiley Online Library
Long COVID can sometimes be attributed to organ damage and well‐characterized
pathophysiology, but more often there is no evidence of organ damage or abnormal …
pathophysiology, but more often there is no evidence of organ damage or abnormal …