Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …

Guanine quadruplexes (G4s) are important targets for cancer treatments as their
stabilization has been associated with a reduction of telomere ends or a lower oncogene …

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

Abstract G-quadruplexes (G4) are helical structures found in guanine-rich DNA or RNA
sequences. Generally, their formalism is based on a few dozen structures, which can …

Ruthenium (II) polypyridyl complexes (RPCs) that emit from metal-to-ligand charge transfer
(MLCT) states have been developed as DNA probes and are being examined as potential …

Human telomeric G‐quadruplex DNA structures are attractive anticancer drug targets, but
the target's polymorphism complicates the drug design: different ligands prefer different …

Mitochondrial DNA (mtDNA) is known to play a critical role in cellular functions. However,
the fluorescent probe enantio-selectively targeting live-cell mtDNA is rare. We recently found …

The DNA G-quadruplex is known for forming a range of topologies and for the observed
lability of the assembly, consistent with its transient formation in live cells. The stabilization of …

Molecular dynamics (MD) simulations for RNA tetramers r (AAAA), r (CAAU), r (GACC), and r
(UUUU) are benchmarked against 1H–1H NOESY distances and 3 J scalar couplings to test …

Abstract G-quadruplex (G4) structures play integral roles in modulating biological functions
and can be regulated by small molecules. The MYC gene is critical during tumor initiation …