Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport
Perivascular spaces are important highways for fluid and solute transport in the brain
enabling efficient waste clearance during sleep. However, the underlying mechanisms …
enabling efficient waste clearance during sleep. However, the underlying mechanisms …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
Neurovascular coupling: motive unknown
PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …
coupling. The common explanation for increased blood flow (known as functional …
Cerebrospinal fluid flow
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …
through the brain transports not only those water-like fluids but also any solutes they carry …
The interconnected causes and consequences of sleep in the brain
LD Lewis - Science, 2021 - science.org
Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
NL Hauglund, M Andersen, K Tokarska, T Radovanovic… - Cell, 2025 - cell.com
As the brain transitions from wakefulness to sleep, processing of external information
diminishes while restorative processes, such as glymphatic removal of waste products, are …
diminishes while restorative processes, such as glymphatic removal of waste products, are …
Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows
Quantifying the flow of cerebrospinal fluid (CSF) is crucial for understanding brain waste
clearance and nutrient delivery, as well as edema in pathological conditions such as stroke …
clearance and nutrient delivery, as well as edema in pathological conditions such as stroke …