Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation
levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Abstract Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of
physiological and pathological processes, including aging and aging-related diseases …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely
interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory …