Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

In recent years, ACE Inhibitors (ACEIs) and Angiotensin II receptor antagonists (also known
as AT1 receptor antagonists (AT1-RAs), angiotensin receptor blockers (ARBs), or Sartans) …

Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-
Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are …

Hypertension is characterized by an imbalance between the renin–angiotensin system
(RAS) and the kallikrein–kinin system (KKS). Angiotensin-converting enzyme inhibitors …

Objective We aimed to broaden our understanding of a potential interaction between B1R
and TLR4, considering earlier studies suggesting that lipopolysaccharide (LPS) may trigger …

Phospholipase A 2 is a known aggravator of inflammation and deteriorates neurological
outcomes after traumatic brain injury (TBI), however the exact inflammatory mechanisms …

Abstract During ischemia/reperfusion (IR), increased activation of angiotensin AT 1
receptors recruits NADPH oxidase 2 (NOX2) which contributes to oxidative stress. It is …

Abstract Angiotensin II (Ang II), a mitogen-activated peptide, exerts numerous effects on the
cardiovascular system including the regulation of blood pressure. The current study focused …

B1-and B2-kinin receptors are G protein-coupled receptors that play an important role in the
vascular function. Therefore, the present study was designed to evaluate the participation of …

Aim The pathophysiology of periodontal diseases involves aspects of immunity and bone
remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and …