Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Endothelial-mesenchymal transition in cardiovascular disease

Z Alvandi, J Bischoff - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms

C Baldini, FR Moriconi, S Galimberti… - European Heart …, 2021 - academic.oup.com
Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

[HTML][HTML] Acetate controls endothelial-to-mesenchymal transition

X Zhu, Y Wang, I Soaita, HW Lee, H Bae, N Boutagy… - Cell Metabolism, 2023 - cell.com
Endothelial-to-mesenchymal transition (EndMT), a process initiated by activation of
endothelial TGF-β signaling, underlies numerous chronic vascular diseases and fibrotic …

Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence

PK Lin, GE Davis - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …

Tenascin-X mediates flow-induced suppression of EndMT and atherosclerosis

G Liang, SP Wang, J Shao, YJ **, L Xu, Y Yan… - Circulation …, 2022 - Am Heart Assoc
Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a
critical driver of vascular inflammation and atherosclerosis, and TGF-β (transforming growth …

Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall

S Ananthaseshan, K Bojakowski, M Sacharczuk… - Scientific Reports, 2022 - nature.com
The mechanism underlying the association between elevated red cell distribution width
(RDW) and poor prognosis in variety of diseases is unknown although many researchers …

Endothelial-to-mesenchymal transition: An underappreciated mediator of diabetic complications

E Wang, H Wang, S Chakrabarti - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes and its complications represent a great burden on the global healthcare system.
Diabetic complications are fundamentally diseases of the vasculature, with endothelial cells …

Endothelial to mesenchymal transition: an insight in atherosclerosis

Q Huang, Y Gan, Z Yu, H Wu, Z Zhong - Frontiers in cardiovascular …, 2021 - frontiersin.org
Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high
morbidity and mortality worldwide. The endothelium is the first protective barrier in …

The gut–vascular barrier as a new protagonist in intestinal and extraintestinal diseases

N Di Tommaso, F Santopaolo, A Gasbarrini… - International Journal of …, 2023 - mdpi.com
The intestinal barrier, with its multiple layers, is the first line of defense between the outside
world and the intestine. Its disruption, resulting in increased intestinal permeability, is a …