Machine learning based toxicity prediction: from chemical structural description to transcriptome analysis

Y Wu, G Wang - International journal of molecular sciences, 2018‏ - mdpi.com
Toxicity prediction is very important to public health. Among its many applications, toxicity
prediction is essential to reduce the cost and labor of a drug's preclinical and clinical trials …

[HTML][HTML] Deep learning for genomics: from early neural nets to modern large language models

T Yue, Y Wang, L Zhang, C Gu, H Xue, W Wang… - International Journal of …, 2023‏ - mdpi.com
The data explosion driven by advancements in genomic research, such as high-throughput
sequencing techniques, is constantly challenging conventional methods used in genomics …

A review on prediction and prognosis of the prostate cancer and gleason grading of prostatic carcinoma using deep transfer learning based approaches

GP Kanna, SJKJ Kumar, P Parthasarathi… - … Methods in Engineering, 2023‏ - Springer
Prostate cancer is a dangerous type of cancer that kills a lot of men because it is hard to
diagnose. Images taken of people with carcinoma have complex and important parts that are …

Breast cancer prediction from microRNA profiling using random subspace ensemble of LDA classifiers via Bayesian optimization

SK Sharma, K Vijayakumar, VJ Kadam… - Multimedia Tools and …, 2022‏ - Springer
Breast cancer rates are rising. It also remains the second principal reason for cancer-related
mortality in females, and the mortality rate is also drastically rising. In recent years …

Out-of-distribution generalization from labelled and unlabelled gene expression data for drug response prediction

H Sharifi-Noghabi, PA Harjandi, O Zolotareva… - Nature Machine …, 2021‏ - nature.com
Data discrepancy between preclinical and clinical datasets poses a major challenge for
accurate drug response prediction based on gene expression data. Different methods of …

AITL: adversarial inductive transfer learning with input and output space adaptation for pharmacogenomics

H Sharifi-Noghabi, S Peng, O Zolotareva… - …, 2020‏ - academic.oup.com
Motivation The goal of pharmacogenomics is to predict drug response in patients using their
single-or multi-omics data. A major challenge is that clinical data (ie patients) with drug …

Biological interpretation of deep neural network for phenotype prediction based on gene expression

B Hanczar, F Zehraoui, T Issa, M Arles - BMC bioinformatics, 2020‏ - Springer
Background The use of predictive gene signatures to assist clinical decision is becoming
more and more important. Deep learning has a huge potential in the prediction of phenotype …

Feature selection with ensemble learning for prostate cancer diagnosis from microarray gene expression

A Gumaei, R Sammouda… - Health Informatics …, 2021‏ - journals.sagepub.com
Cancer diagnosis using machine learning algorithms is one of the main topics of research in
computer-based medical science. Prostate cancer is considered one of the reasons that are …

[PDF][PDF] DeepHealth: Deep Learning for Health Informatics reviews, challenges, and opportunities on medical imaging, electronic health records, genomics, sensing …

GHJ Kwak, P Hui - arxiv preprint arxiv:1909.00384, 2019‏ - researchgate.net
CCS Concepts:• Computing methodologies→ Machine learning approaches; Machine
learning;• Social and professional topics→ Computing/technology policy; Medical …

MetastaSite: Predicting metastasis to different sites using deep learning with gene expression data

S Albaradei, A Albaradei, A Alsaedi… - Frontiers in Molecular …, 2022‏ - frontiersin.org
Deep learning has massive potential in predicting phenotype from different omics profiles.
However, deep neural networks are viewed as black boxes, providing predictions without …