Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance
of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation …

Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize
prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified …

Background Leukocyte telomere length (LTL) is related to prostate cancer (PCa). However,
the causal relationship between them remains unknown. This study was aimed at identifying …

Prostate cancer (PCa) is one of the most prevalent cancers in men. Cancer stem cells are
thought to be associated with PCa relapse. Here, we show that BAZ2A is required for PCa …

Genetic variation at the 19q13. 3 KLK locus is linked with prostate cancer susceptibility in
men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c …

To realize the goals of precision medicine in complex disease, discriminative clinical risk
models are needed. One approach that has been proposed is polygenic risk scores (PRSs) …

Background Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer
with poor survival. Comprehensive molecular profiles and putative therapeutic targets of …

Prostate cancer is one of the most common malignant tumors in men. Pyroptosis is related to
tumor immune infiltration and tumor microenvironment (TME) and has been confirmed to be …

Background Although the sphingolipid metabolism pathway is known to play a significant
role in tumor progression, there have been few studies on how genetic variants in the …