Neutrophils in COVID-19
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …
neutrophils play an important role in the pathophysiology, particularly in those with severe …
Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution
African swine fever virus (ASFV) is the causative agent of African swine fever, a highly
contagious and usually fatal disease in pigs. The pathogenesis of ASFV infection has not …
contagious and usually fatal disease in pigs. The pathogenesis of ASFV infection has not …
SingPro: a knowledge base providing single-cell proteomic data
Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro
Bacterial sepsis and severe COVID-19 share similar clinical manifestations and are both
associated with dysregulation of the myeloid cell compartment. We previously reported an …
associated with dysregulation of the myeloid cell compartment. We previously reported an …
Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques
Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are
pivotal mediators of the immune response, yet little is known about their properties at the …
pivotal mediators of the immune response, yet little is known about their properties at the …
Understanding virus–host interactions in tissues
E Speranza - Nature Microbiology, 2023 - nature.com
Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …
in immortalized cell lines or isolated cell populations, it is important to remember that what is …
Functional single-cell genomics of human cytomegalovirus infection
Understanding how viral and host factors interact and how perturbations impact infection is
the basis for designing antiviral interventions. Here we define the functional contribution of …
the basis for designing antiviral interventions. Here we define the functional contribution of …
[HTML][HTML] CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
JD Bromley, SKC Ganchua, SK Nyquist, P Maiello… - Immunity, 2024 - cell.com
Immunological priming—in the context of either prior infection or vaccination—elicits
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …