Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

African swine fever virus (ASFV) is the causative agent of African swine fever, a highly
contagious and usually fatal disease in pigs. The pathogenesis of ASFV infection has not …

African swine fever, one of the major viral diseases of swine, poses an imminent threat to the
global pig industry. The high-efficient replication of the causative agent African swine fever …

Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …

Bacterial sepsis and severe COVID-19 share similar clinical manifestations and are both
associated with dysregulation of the myeloid cell compartment. We previously reported an …

Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …

Understanding how viral and host factors interact and how perturbations impact infection is
the basis for designing antiviral interventions. Here we define the functional contribution of …

Immunological priming—in the context of either prior infection or vaccination—elicits
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …