Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting
in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt …

Vitamin D plays an important role in calcium homeostasis and bone metabolism, with the
capacity to modulate innate and adaptive immune function, cardiovascular function, and …

ABSTRACT Fibroblast growth factor‐23 (Fgf23) is a bone‐derived hormone, suppressing
phosphate reabsorption and vitamin D hormone (1, 25 (OH) 2D3) production in the kidney. It …

Highlights•Pyrophosphate prevents unwanted calcification making it the body's natural
'water-softener'.•The breakdown of ATP released from cells represents a key source of …

The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by
calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed …

Osteocytes, entrapped within a newly mineralized bone matrix, possess a unique cellular
identity due to a specialized morphology and a molecular signature. These features endow …

Arterial calcification is an important hallmark of cardiovascular disease and shares many
similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an …

The human cardiovascular system is a complex arrangement of specialized structures with
distinct functions. The molecular landscape, including the genome, transcriptome and …