The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

A Nabavi-Rad, A Sadeghi, H Asadzadeh Aghdaei… - Gut …, 2022 - Taylor & Francis
As Helicobacter pylori management has become more challenging and less efficient over
the last decade, the interest in innovative interventions is growing by the day. Probiotic co …

Emerging role of aging in the progression of NAFLD to HCC

Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

[HTML][HTML] Liver fibrosis: From basic science towards clinical progress, focusing on the central role of hepatic stellate cells

H Akkız, RK Gieseler, A Canbay - International Journal of Molecular …, 2024 - mdpi.com
The burden of chronic liver disease is globally increasing at an alarming rate. Chronic liver
injury leads to liver inflammation and fibrosis (LF) as critical determinants of long-term …

Delivery strategy to enhance the therapeutic efficacy of Liver Fibrosis via Nanoparticle Drug Delivery systems

J Liu, J Liu, W Mu, Q Ma, X Zhai, B **, Y Liu, N Zhang - ACS nano, 2024 - ACS Publications
Liver fibrosis (LF) is a pathological repair reaction caused by a chronic liver injury that affects
the health of millions of people worldwide, progressing to life-threatening cirrhosis and liver …

CREKA-modified liposomes target activated hepatic stellate cells to alleviate liver fibrosis by inhibiting collagen synthesis and angiogenesis

R Li, J Zhang, Q Liu, Q Tang, Q Jia, Y **ong, J He, Y Li - Acta Biomaterialia, 2023 - Elsevier
Activated hepatic stellate cells (HSCs) are considered the key driver of excessive
extracellular matrix and abnormal angiogenesis, which are the main pathological …

[HTML][HTML] Non-alcoholic fatty liver disease and liver fibrosis during aging

Y Li, NT Adeniji, W Fan, K Kunimoto, NJ Török - Aging and disease, 2022 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease-related …

Recent advancements in antifibrotic therapies for regression of liver fibrosis

A Jangra, A Kothari, P Sarma, B Medhi, BJ Omar… - Cells, 2022 - mdpi.com
Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …

Omega-3 lipid mediators: modulation of the M1/M2 macrophage phenotype and its protective role in chronic liver diseases

LA Videla, R Valenzuela, A Del Campo… - International Journal of …, 2023 - mdpi.com
The complex interplay between dietary factors, inflammation, and macrophage polarization
is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 …

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis

Y Zhang, Y Wu, W Shen… - Molecular medicine …, 2022 - spandidos-publications.com
Liver fibrosis is a common pathological process of chronic liver diseases, including viral
hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and …

Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

M Ma, N Wei, J Yang, T Ding, A Song… - Pharmaceutical …, 2023 - Taylor & Francis
Abstract Context Schisandrin B (Sch B), an active ingredient from Schisandrae chinensis
(Turcz.) Baill.(Schisandraceae) Fructus, possesses diverse pharmacological activities …