Leukodystrophies are genetically determined disorders characterized by the selective
involvement of the central nervous system white matter. Onset may be at any age, from …

Oligodendroglial pathology is central to de‐and dysmyelinating, but also contributes to
neurodegenerative and psychiatric diseases as well as brain injury. The understanding of …

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced
pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to …

Neural stem and precursor cells (NPCs) build and regenerate the central nervous system
(CNS) by maintaining their pool (self-renewal) and differentiating into neurons, astrocytes …

Oligodendrocytes are a type of glial cells that produce a lipid‐rich membrane called myelin.
Myelin assembles into a sheath and lines neuronal axons in the brain and spinal cord to …

Pelizaeus–Merzbacher disease (PMD) is an X-linked disorder caused by mutations in the
PLP1 gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD …

Remyelination failure in multiple sclerosis (MS) is associated with a migration/differentiation
block of oligodendroglia. The reason for this block is highly debated. It could result from …

Pelizaeus–Merzbacher Disease (PMD) is an inherited leukodystrophy affecting the central
nervous system (CNS)—a rare disorder that especially concerns males. Its estimated …

Proteolipid protein (PLP) is the most abundant integral membrane protein in compact central
nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type …

The mammalian adult brain contains two neural stem and precursor (NPC) niches: the
subventricular zone [SVZ] lining the lateral ventricles and the subgranular zone [SGZ] in the …