Prospects of topoisomerase inhibitors as promising anti-cancer agents
Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …
biological actions like DNA replication, transcription, and repair. The emergence and spread …
Advances in alkynyl gold complexes for use as potential anticancer agents
Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …
chemists due to their unique chemical properties and strong antiproliferative potency …
[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …
Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic …
A series of new pyrazolo-benzothiazole hybrids (7–26) were synthesised and screened for
their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung …
their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung …
Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: synthesis, in silico and cell growth inhibition studies
An approach in modern medicinal chemistry to discover novel bioactive compounds is by
mimicking diverse complementary pharmacophores. In extension of this strategy, a new …
mimicking diverse complementary pharmacophores. In extension of this strategy, a new …
Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect
The development of new small molecules from known structural motifs through molecular
hybridization is one of the trends in drug discovery. In this connection, we have combined …
hybridization is one of the trends in drug discovery. In this connection, we have combined …
The challenging melanoma landscape: From early drug discovery to clinical approval
M Matias, JO Pinho, MJ Penetra, G Campos, CP Reis… - Cells, 2021 - mdpi.com
Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …
resistance to currently used treatments. To overcome the limitations of the available …
Functional utility of gold complexes with phosphorus donor ligands in biological systems
Metallo-phosphines are ubiquitous in organometallic chemistry with widespread
applications as catalysts in various chemical transformations, precursors for organic …
applications as catalysts in various chemical transformations, precursors for organic …
[HTML][HTML] Revisiting metallodrugs for the treatment of skin cancers
CM Manzano, DH Nakahata, REF de Paiva - Coordination Chemistry …, 2022 - Elsevier
Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …
peak of the development of platinum anticancer agents. New systematic studies appeared in …
Mechanochemical synthesis of (hetero) aryl Au (i) complexes
Growing demand for sustainable chemical syntheses casts mechanochemistry in a new light
as an environmentally benign alternative to traditional solvent-based methods. Given recent …
as an environmentally benign alternative to traditional solvent-based methods. Given recent …