A challenge during development is to ensure lineage segregation while preserving
plasticity. Using pluripotency progression as a paradigm, we review how developmental …

In the past several decades, the establishment of in vitro models of pluripotency has ushered
in a golden era for developmental and stem cell biology. Research in this arena has led to …

Mutations in AUTS2 are associated with autism, intellectual disability, and microcephaly.
AUTS2 is expressed in the brain and interacts with polycomb proteins, yet it is still unclear …

Hyperactivation of the oncogenic transcription reflects the epigenetic plasticity of the cancer
cells. Su (var) 3-9, enhancer of zeste, Trithorax (SET) was described as a nuclear factor that …

Pluripotent stem cells (PSCs) are important models for analyzing cellular metabolism and
individual development. As a hypoxia‐inducible factor subunit, HIF‐1α plays an important …

Embryonic stem cells (ESCs), with their dual capacity to self-renew and differentiate, are
commonly used to study differentiation, epigenetic regulation, lineage choices, and more …

Patients with diabetes mellitus (DM) have an increased risk of tooth decay caused by
alterations in their tooth development and their oral environment, as well as a tendency to …

Many chromatin remodeling and modifying proteins are involved in the DNA damage
response, where they stimulate repair or induce DNA damage signaling. Interestingly, we …

Dynamicity and flexibility of the chromatin landscape are critical for most of the DNA-
dependent processes to occur. This higher-order packaging of the eukaryotic genome into …

Pluripotency is orchestrated by distinct players and chaperones and their partners have
emerged as pivotal molecules in proteostasis control to maintain stemness. The proteostasis …