The sympathetic nervous system alterations in human hypertension

G Grassi, A Mark, M Esler - Circulation research, 2015 - Am Heart Assoc
Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

Obesity‐related metabolic syndrome: mechanisms of sympathetic overactivity

MP Canale, S Manca di Villahermosa… - International journal …, 2013 - Wiley Online Library
The prevalence of the metabolic syndrome has increased worldwide over the past few
years. Sympathetic nervous system overactivity is a key mechanism leading to hypertension …

Clinical trial design principles and outcomes definitions for device-based therapies for hypertension: a consensus document from the hypertension academic research …

DE Kandzari, F Mahfoud, MA Weber, R Townsend… - Circulation, 2022 - Am Heart Assoc
The clinical implications of hypertension in addition to a high prevalence of both
uncontrolled blood pressure and medication nonadherence promote interest in develo** …

[HTML][HTML] Updated ESH position paper on interventional therapy of resistant hypertension

RE Schmieder, J Redon, G Grassi, SE Kjeldsen… - 2013 - eurointervention.pcronline.com
Out of the overall hypertensive population it is estimated that approximately 10% have
treatment resistant hypertension (TRH). Percutaneous catheter-based transluminal renal …

Sympathetic overactivity in chronic kidney disease: consequences and mechanisms

J Kaur, BE Young, PJ Fadel - International journal of molecular sciences, 2017 - mdpi.com
The incidence of chronic kidney disease (CKD) is increasing worldwide, with more than 26
million people suffering from CKD in the United States alone. More patients with CKD die of …

Renal Denervation and Symplicity HTN-3: “Dubium Sapientiae Initium” (Doubt Is the Beginning of Wisdom)

V Papademetriou, C Tsioufis, M Doumas - Circulation research, 2014 - Am Heart Assoc
212 Circulation Research July 7, 2014 and others19, 20 confirmed and re-enforced these
observations. Furthermore, Osborn et al21 demonstrated that low-frequency stimulation of …

Renal denervation: a review

J Rey-García, RR Townsend - American Journal of Kidney Diseases, 2022 - Elsevier
Uncontrolled hypertension persists as an important health issue despite the availability of
many medications and nondrug therapies that lower blood pressure. Increasingly …

Renal nerve ablation for resistant hypertension: how did we get here, present status, and future directions

V Papademetriou, AA Rashidi, C Tsioufis, M Doumas - Circulation, 2014 - Am Heart Assoc
Papademetriou et al Renal Nerve Ablation: Perspectives 1441 the procedure of choice for
patients with severe/malignant hypertension not responding to diet or to then-limited …

[HTML][HTML] Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation

D Hering, MD Esler, MP Schlaich - 2013 - eurointervention.pcronline.com
The prevalence of chronic kidney disease (CKD) and end-stage renal disease continues to
increase worldwide. Hypertension and diabetes are recognised as two major factors …

International expert consensus statement: percutaneous transluminal renal denervation for the treatment of resistant hypertension

MP Schlaich, RE Schmieder, G Bakris… - Journal of the American …, 2013 - jacc.org
Catheter-based radiofrequency ablation technology to disrupt both efferent and afferent
renal nerves has recently been introduced to clinical medicine after the demonstration of …