Sonodynamic therapy (SDT) has gained significant attention in the treatment of deep tumors
and multidrug-resistant (MDR) bacterial infections due to its high tissue penetration depth …

Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

Abstract Background Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate
consisting of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a …

Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …

Introduction This pooled analysis of nine phase I and II trastuzumab deruxtecan (T-DXd)
monotherapy studies described drug-related interstitial lung disease (ILD)/pneumonitis in …

Abstract Background Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate
composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a …

Abstract Trastuzumab deruxtecan (T-DXd; DS-8201) is an antibody-drug conjugate targeting
human epidermal growth factor receptor 2. Interstitial lung disease (ILD)/pneumonitis is an …

Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …