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The develo** human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all
lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To …

While Crohn disease (CD) has been clearly identified as a Th1 inflammation, the
immunopathogenesis of its counterpart inflammatory bowel disease, ulcerative colitis (UC) …

CD1d-restricted autoreactive natural killer (NK) T cells have been reported to regulate a
range of disease conditions, including type I diabetes and immune rejection of cancer …

The proposed roles of NK1. 1+ T (NKT) cells in immune responses range from suppression
of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the …

Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the
invariant Vα14–Jα18 T-cell receptor (known here as Vα14 i T cells) from conventional T …

NK1. 1 and its human homolog CD161 are expressed on NK cells, subsets of CD4+ and
CD8+ T cells, and NKT cells. While the expression of NK1. 1 is thought to be inhibitory to NK …