Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

During tumor progression, lysosome function is often maladaptively upregulated to match
the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

During primary tumorigenesis isolated cancer cells may undergo genetic or epigenetic
changes that render them responsive to additional intrinsic or extrinsic cues, so that they …

Cancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic
potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication …

To date, cancer remains a worldwide leading cause of death, with a still rising incidence.
This is essentially caused by the fact, that despite the abundance of therapeutic targets and …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …