Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems
(Cas) are efficient tools for targeting specific genes for laboratory research, agricultural …

RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …

Photothermal therapy (PTT) normally requires to maintain the temperature of tumor lesions
above 50° C, which potentially induces local inflammation and tumor metastasis. To avoid …

Nucleophilic amino acids make important contributions to protein function, including
performing key roles in catalysis and serving as sites for post-translational modification …

Chemical probes are powerful reagents with increasing impacts on biomedical research.
However, probes of poor quality or that are used incorrectly generate misleading results. To …

Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

Effective and safe delivery of anticancer agents is among the major challenges in cancer
therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability …

Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-
refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To …

Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …

Small-molecule chemical probes are among the most important tools to study the function of
proteins in cells and organisms. Regrettably, the use of weak and non-selective small …