Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases

P Chaudhary, P Janmeda, AO Docea… - Frontiers in …, 2023‏ - frontiersin.org
Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

Anticancer drug discovery based on natural products: From computational approaches to clinical studies

P Chunarkar-Patil, M Kaleem, R Mishra, S Ray… - Biomedicines, 2024‏ - mdpi.com
Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

MR Hasan, BS Alotaibi, ZM Althafar, AH Mujamammi… - Molecules, 2023‏ - mdpi.com
In most cases, cancer develops due to abnormal cell growth and subsequent tumour
formation. Due to significant constraints with current treatments, natural compounds are …

Antioxidant and anti‐inflammatory mechanisms of neuroprotection by ursolic acid: Addressing brain injury, cerebral ischemia, cognition deficit, anxiety, and …

S Habtemariam - Oxidative medicine and cellular longevity, 2019‏ - Wiley Online Library
Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal
plants that are reputed for a variety of pharmacological effects. Both as an active principle of …

Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives

F Seif, Z Torki, H Zalpoor, M Habibi… - Molecular Therapy …, 2023‏ - cell.com
The tumor microenvironment (TME) comprises a variety of immune cells, among which T
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …

Plant-extract mediated green approach for the synthesis of ZnONPs: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials

J Iqbal, BA Abbasi, T Mahmood, S Kanwal… - Journal of Molecular …, 2019‏ - Elsevier
Plant-extract-mediated green synthesis of nanoparticles is significantly attracting the
attention of scientific community due to its simple, cost-effective, energy-efficient and eco …

Ursolic acid: A natural modulator of signaling networks in different cancers

S Zafar, K Khan, A Hafeez, M Irfan, M Armaghan… - Cancer Cell …, 2022‏ - Springer
Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the
development of resistance against currently available treatment strategies has contributed to …

[HTML][HTML] Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells

NH Nguyen, QTH Ta, QT Pham, TNH Luong, VT Phung… - Molecules, 2020‏ - mdpi.com
Cancer is the second leading cause of death globally, and despite the advances in drug
development, it is still necessary to develop new plant-derived medicines. Compared with …

Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

BA Abbasi, J Iqbal, R Ahmad, L Zia, S Kanwal… - Biomolecules, 2019‏ - mdpi.com
This study attempts to obtain and test the bioactivities of leaf extracts from a medicinal plant,
Geranium wallichianum (GW), when conjugated with zinc oxide nanoparticles (ZnONPs) …

A review on the phytochemical and pharmacological properties of Hyptis suaveolens (L.) Poit

P Mishra, S Sohrab, SK Mishra - Future Journal of Pharmaceutical …, 2021‏ - Springer
Background Plants are the repository of variable number of valuable secondary metabolites
that bears pharmacognostic and pharmacological implications having potentiality to emerge …