Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric
complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes …

Background Whether prehospital administration of tranexamic acid increases the likelihood
of survival with a favorable functional outcome among patients with major trauma and …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Background Each year, worldwide, about 3 million people die as a result of trauma, many
after reaching hospital. Among trauma patients who do survive to reach hospital, bleeding is …

BACKGROUND: The aim of the CRASH-2 trial was to assess the effects of early
administration of tranexamic acid on death, vascular occlusive events, and blood transfusion …

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Background: Blood transfusions are associated with morbidity and mortality. However,
restrictive thresholds could harm patients less able to tolerate anemia. Using a context …

Coagulation abnormalities are commonly found in critically ill patients. A myriad of altered
coagulation parameters are often detectable, such as thrombocytopenia, prolonged global …