Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Over the past decade, CRISPR/Cas-based gene editing has become a powerful tool for
generating mutations in a variety of model organisms, from Escherichia coli to zebrafish …

Linking variants from genome-wide association studies (GWAS) to underlying mechanisms
of disease remains a challenge,–. For some diseases, a successful strategy has been to …

To enable rapid propagation of action potentials, axons are ensheathed by myelin, a
multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is …

Copper is an essential trace element for the human body, and its requirement for optimistic
immune functions has been recognized for decades. How copper is involved in the innate …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Organisms evolve mechanisms that regulate the properties of biogenic crystals to support a
wide range of functions, from vision and camouflage to communication and thermal …

The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …

Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …

Neurons on the left and right sides of the nervous system often show asymmetric properties,
but how such differences arise is poorly understood. Genetic screening in zebrafish …