Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …

Substituted hydroxymethylenebisphosphonic acid derivatives–either as dronic acids or their
dronate sodium salts, are important pharmaceuticals in the treatment of diseases arising …

A century after their discovery, phosphonates have become important compounds
recognized both for their use as efficient reagents in organic synthesis and for their …

Despite being one of the first-line treatments for osteoporosis, the bis phosphonate drug
class exhibits an extremely low oral bioavailability (< 1%) due to poor absorption from the …

Alendronate derivatives were evaluated as potential prodrugs for the osteoporosis drug
alendronate sodium in an attempt to enhance the systemic exposure after oral …

Background: Methylenebisphosphonic derivatives including hydroxy-
methylenebisphosphonic species may be of potential biological activity, and a part of them is …

The microwave (MW)‐assisted addition of dialkyl phosphites to α‐oxophosphonates was
investigated and optimized under solventless conditions to provide the phenyl‐and benzyl …

New hydroxy-methylenebisphosphonic derivatives were prepared with different P-functions.
The outcome of the reaction of α-oxophosphonates (YC (O) P (O)(OR) 2) and dialkyl …

Under atmospheric hydrogen pressure, a catalytic amount of palladium (II) trifluoroacetate
and (R)‐MeO‐BIPHEP in 2, 2, 2‐trifluoroethanol promoted the asymmetric hydrogenation of …

The reaction of diethyl α-oxoethylphosphonate and diethyl oxobenzylphosphonate with
diethyl phosphite, dimethyl phosphite, and diphenylphosphine oxide affords, depending on …