Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible
conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD (P)+ to NAD …

Leucine, a branched-chain amino acid that must be supplied in the daily diet, plays an
important role in controlling protein synthesis and regulating cell metabolism in various cell …

Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains
unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) …

The cancer metastasis process involves dysregulated oncogenic kinase signaling, but how
this orchestrates metabolic networks and signal cascades to promote metastasis is largely …

A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …

Glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to α-
ketoglutarate and ammonia. High levels of GDH activity is found in mammalian liver, kidney …

Human evolution is characterized by rapid brain enlargement and the emergence of unique
cognitive abilities. Besides its distinctive cytoarchitectural organization and extensive inter …

There are two paralogs of glutamate dehydrogenase (GDH) in humans encoded by the
GLUD1 and GLUD2 genes as a result of a recent retroposition during the evolution of …

Glutamate dehydrogenase (GDH), an enzyme central to glutamate metabolism, is located in
the mitochondria although there is evidence for extramitochondrial localization of GDH. In …