Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …

The small mammalian mitochondrial DNA (mtDNA) is very gene dense and encodes factors
critical for oxidative phosphorylation. Mutations of mtDNA cause a variety of human …

Objective Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS).
Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely …

Mitochondrial dysfunction is heavily implicated in Parkinson disease (PD) as exemplified by
the finding of an increased frequency of respiratory chain-deficient dopamine (DA) neurons …

Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative
phosphorylation capacity in mammals. The MTERF protein family plays a key role in this …

Somatic mutations of mtDNA are implicated in the aging process, but there is no universally
accepted method for their accurate quantification. We have used ultra-deep sequencing to …

Two paradigms central to geroscience research are that aging is associated with increased
oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers …

How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

Background The unique metabolism of tumors was described many years ago by Otto
Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial …

Oxidative stress is the resultant damage that arises due to redox imbalances, more
specifically an increase in destructive free radicals and reduction in protection from …